| WeeksJohn W. Weeks (R-MA) | 1916 |
| GallingerJacob H. Gallinger (R-NH) | 1918 |
| PoindexterMiles Poindexter (R, PR-WA) | 1920–1921 |
| McCormickJoseph M. McCormick (R-IL) | 1921–1922 |
| MosesGeorge H. Moses (R-NH) | 1922–1924 |
| FessSimeon D. Fess (R-OH) | 1925–1926 |
| Phipps Lawrence C. Phipps (R-CO) | 1926–1927 |
| MosesGeorge H. Moses (R-NH) | 1927–1928 |
| Metcalf Jesse H. Metcalf (R-RI) | 1928–1929 |
| MosesGeorge H. Moses (R-NH) | 1929–1930 |
| NyeGerald P. Nye (R-ND) | 1930–1931 |
| HatfieldHenry D. Hatfield (R-WV) | 1931–1932 |
| DickinsonLester J. Dickinson (R-IA) | 1932–1934 |
| HastingsDaniel O. Hastings (R-DE) | 1934–1936 |
| TownsendJohn G. Townsend, Jr. (R-DE)
1
| 1936–1949 |
| BrewsterRalph O. Brewster (R-ME) | 1949–1951 |
| BridgesH. Styles Bridges (R-NH) | 1951–1953 |
| DirksenEverett M. Dirksen (R-IL) | 1953–1955 |
| GoldwaterBarry M. Goldwater (R-AZ) | 1955–1956 |
| SchoeppelAndrew F. Schoeppel (R-KS) | 1956–1959 |
| GoldwaterBarry M. Goldwater (R-AZ) | 1959–1963 |
| MortonThruston B. Morton (R-KY) | 1963–1967 |
| MurphyGeorge L. Murphy (R-CA) | 1967–1969 |
| TowerJohn G. Tower (R-TX) | 1969–1971 |
| DominickPeter H. Dominick (R-CO) | 1971–1973 |
| BrockWilliam E. Brock III (R-TN) | 1973–1975 |
| StevensTed Stevens (R-AK) | 1975–1977 |
| PackwoodRobert W. Packwood (R-OR) | 1977–1979 |
| HeinzH. John Heinz III (R-PA) | 1979–1981 |
| PackwoodRobert W. Packwood (R-OR) | 1981–1983 |
| LugarRichard G. Lugar (R-IN) | 1983–1985 |
| HeinzH. John Heinz III (R-PA) | 1985–1987 |
| BoschwitzRudy Boschwitz (R-MN) | 1987–1989 |
| NicklesDonald L. Nickles (R-OK) | 1989–1991 |
| GrammPhil Gramm (R-TX) | 1991–1995 |
| D'AmatoAlfonse M. D'Amato (R-NY) | 1995–1997 |
| McConnellMitch McConnell (R-KY) | 1997–2001 |
| FristWilliam H. Frist (R-TN) | 2001–2003 |
| AllenGeorge Allen (R-VA) | 2003–2005 |
| DoleElizabeth H. Dole (R-NC) | 2005–2007 |
| EnsignJohn E. Ensign (R-NV) | 2007–2008 |
| CornynJohn Cornyn (R-TX) | 2009–2013 |
| MoranJerry Moran (R-KS) | 2013–2015 |
| WickerRoger F. Wicker (R-MS) | 2015–2017 |
| GardnerCory Gardner (R-CO) | 2017–2019 |
| YoungTodd Young (R-IN) | 2019–2021 |
| ScottRick Scott (R-FL) | 2021–2023 |
| DainesSteve Daines (R-MT) | 2023–present |
