| SaulsburyWillard Saulsbury, Jr. (D-DE) | 1916 |
| WalshThomas J. Walsh (D-MT) | 1920–1922 |
| WalshDavid I. Walsh (D-MA) | 1922–1924 |
| JonesAndrieus A. Jones (D-NM) | 1924–1926 |
| GerryPeter G. Gerry (D-RI) | 1926–1928 |
| Tydings Millard E. Tydings (D-MD) | 1928–1932 |
| Swanson Claude A. Swanson (D-VA) | 1932–1934 |
| LewisJames H. Lewis (D-IL) | 1934–1935 |
| Guffey Joseph F. Guffey (D-PA) | 1935–1937 |
| BrownPrentiss M. Brown (D-MI) | 1938–1939 |
| GreenTheodore F. Green (D-RI) | 1939–1941 |
| GuffeyJoseph F. Guffey (D-PA) | 1941–1943 |
| O'MahoneyJoseph C. O'Mahoney (D-WY) | 1943–1947 |
| LucasScott W. Lucas (D-IL) | 1947–1949 |
| AndersonClinton Presba Anderson (D-NM) | 1949–1953 |
| ClementsEarle C. Clements (D-KY) | 1953–1957 |
| SmathersGeorge A. Smathers (D-FL) | 1957–1961 |
| HartkeRupert V. Hartke (D-IN) | 1961–1963 |
| MagnusonWarren G. Magnuson (D-WA) | 1963–1967 |
| MuskieEdmund S. Muskie (D-ME) | 1967–1969 |
| InouyeDaniel K. Inouye (D-HI) | 1969–1971 |
| HollingsFritz Hollings (D-SC) | 1971–1973 |
| BentsenLloyd M. Bentsen, Jr. (D-TX) | 1973–1976 |
| JohnstonJ. Bennett Johnston, Jr. (D-LA) | 1976–1977 |
| FordWendell H. Ford (D-KY) | 1977–1983 |
| BentsenLloyd M. Bentsen, Jr. (D-TX) | 1983–1985 |
| MitchellGeorge J. Mitchell (D-ME) | 1985–1987 |
| KerryJohn F. Kerry (D-MA) | 1987–1989 |
| BreauxJohn B. Breaux (D-LA) | 1989–1991 |
| RobbCharles S. Robb (D-VA) | 1991–1993 |
| GrahamBob Graham (D-FL) | 1993–1995 |
| KerreyJ. Robert Kerrey (D-NE) | 1995–1999 |
| TorricelliRobert G. Torricelli (D-NJ) | 1999–2001 |
| MurrayPatty Murray (D-WA) | 2001–2003 |
| CorzineJon S. Corzine (D-NJ) | 2003–2005 |
| SchumerCharles E. Schumer (D-NY) | 2005–2008 |
| MenendezRobert Menendez (D-NJ) | 2008–2011 |
| MurrayPatty Murray (D-WA) | 2011–2013 |
| BennetMichael F. Bennet (D-CO) | 2013–2015 |
| TesterJon Tester (D-MT) | 2015–2017 |
| Van HollenChris Van Hollen (D-MD) | 2017–2019 |
| Cortez MastoCatherine Cortez Masto (D-NV) | 2019–2021 |
| PetersGary C. Peters (D-MI) | 2021–present |
