| CONGRESS | SENATOR | TERM BEGAN | TERM ENDED | COMMENTS |
|---|---|---|---|---|
| Class 1 | ||||
| 1st | Tristram Dalton (Pro-Admin) | Mar. 4, 1789 | Mar. 3, 1791 | |
| 2nd-4th | George Cabot (Pro-Admin) | Mar. 4, 1791 | Jun. 9, 1796 | Resigned |
| 4th-6th | Benjamin Goodhue (F) | Jun. 11, 1796 | Nov. 8, 1800 | Resigned |
| 6th-7th | Jonathan Mason (F) | Nov. 14, 1800 | Mar. 3, 1803 | |
| 8th-10th | John Quincy Adams (F) | Mar. 4, 1803 | Jun. 8, 1808 | Resigned |
| 10th-13th | James Lloyd (F, Adams-Clay F, Adams) | Jun. 9, 1808 | May 1, 1813 | Resigned |
| 13th-14th | Christopher Gore (F) | May 5, 1813 | May 30, 1816 | Appointed then elected; Resigned |
| 14th-15th | Eli P. Ashmun (F) | Jun. 12, 1816 | May 10, 1818 | Resigned |
| 15th-16th | Prentiss Mellen (F) | Jun. 5, 1818 | May 15, 1820 | Resigned |
| 16th-19th | Elijah H. Mills (F, Adams-Clay F, Adams) | Jun. 12, 1820 | Mar. 3, 1827 | |
| 20th-26th | Daniel Webster (Adams, AJ, W) | May 30, 1827 | Feb. 22, 1841 | Resigned |
| 26th-28th | Rufus Choate (W) | Feb. 23, 1841 | Mar. 3, 1845 | |
| 29th-31st | Daniel Webster (Adams, AJ, W) | Mar. 4, 1845 | Jul. 22, 1850 | Resigned |
| 31st | Robert C. Withrop (W) | Jul. 30, 1850 | Feb. 1, 1851 | Appointed |
| 31st | Robert Rantoul, Jr. (D) | Feb. 1, 1851 | Mar. 3, 1851 | |
| 32nd-43rd | Charles Sumner (FS, OP, R, LR) | Apr. 24, 1851 | Mar. 11, 1874 | Died |
| 43rd | William B. Washburn (R) | Apr. 17, 1874 | Mar. 3, 1875 | |
| 44th-52nd | Henry L. Dawes (R) | Mar. 4, 1875 | Mar. 3, 1893 | |
| 53rd-69th | Henry C. Lodge (R) | Mar. 4, 1893 | Nov. 9, 1924 | Died |
| 69th | William M. Butler (R) | Nov. 13, 1924 | Nov. 13, 1926 | Appointed |
| 69th-79th | David I. Walsh (D) | Dec. 6, 1926 | Jan. 3, 1947 | |
| 80th-82nd | Henry C. Lodge, Jr. (R) | Jan. 3, 1947 | Jan. 3, 1953 | |
| 83rd-87th | John F. Kennedy (D) | Jan. 3, 1953 | Dec. 22, 1960 | Resigned |
| 87th | Benjamin A. Smith II (D) | Dec. 27, 1960 | Nov. 6, 1962 | Appointed |
| 87th-111th | Edward M. Kennedy (Ted) (D) | Nov. 7, 1962 | Aug. 25, 2009 | Died |
| 111th | Paul G. Kirk, Jr. (D) | Sept. 24, 2009 | Feb. 4, 2010 | Appointed |
| 111th-112th | Scott P. Brown (R) | Feb. 4, 2010 | Jan. 3, 2013 | |
| 113th- | Elizabeth Warren (D) | Jan. 3, 2013 | Present | |
| Class 2 | ||||
| 1st-4th | Caleb Strong (Pro-Admin) | Mar. 4, 1789 | Jun. 1, 1796 | Resigned |
| 4th-5th | Theodore Sedgwick (F) | Jun. 11, 1796 | Mar. 3, 1799 | |
| 6th | Samuel Dexter (F) | Mar. 4, 1799 | May 30, 1800 | Resigned |
| 6th-8th | Dwight Foster (F) | Jun. 6, 1800 | Mar. 3, 1803 | Resigned |
| 8th-11th | Timothy Pickering (F) | Mar. 4, 1803 | Mar. 3, 1811 | |
| 12th-14th | Joseph B. Varnum (DR) | Jun. 8, 1811 | Mar. 3, 1817 | |
| 15th-17th | Harrison G. Otis (F) | Mar. 4, 1817 | May 30, 1822 | Resigned |
| 17th-19th | James Lloyd (F, Adams-Clay F, Adams) | Jun. 5, 1822 | May 23, 1826 | Resigned |
| 19th-23rd | Nathaniel Silsbee (Adams) | May 31, 1826 | Mar. 3, 1835 | |
| 24th-26th | John Davis (AJ, W) | Mar. 4, 1835 | Jan. 5, 1841 | Resigned |
| 26th-29th | Isaac C. Bates (W) | Jan. 13, 1841 | Mar. 16, 1845 | Died |
| 29th-32nd | John Davis (AJ, W) | Mar. 24, 1845 | Mar. 3, 1853 | |
| 33rd | Edward Everett (W) | Mar. 4, 1853 | Jun. 1, 1854 | Resigned |
| 33rd | Julius Rockwell (W) | Jun. 3, 1854 | Jan. 31, 1855 | Appointed |
| 33rd-43rd | Henry Wilson (R) | Jan. 31, 1855 | Mar. 3, 1873 | Resigned |
| 43rd-44th | George S. Boutwell (R) | Mar. 12, 1873 | Mar. 3, 1877 | |
| 45th-58th | George F. Hoar (R) | Mar. 4, 1877 | Sept. 30, 1904 | Died |
| 58th-62nd | W. Murray Crane (R) | Oct. 12, 1904 | Mar. 3, 1913 | Appointed, then elected |
| 63rd-65th | John W. Weeks (R) | Mar. 4, 1913 | Mar. 3, 1919 | |
| 66th-68th | David I. Walsh (D) | Mar. 4, 1919 | Mar. 3, 1925 | |
| 69th-71st | Frederick H. Gillett (R) | Mar. 4, 1925 | Mar. 3, 1931 | |
| 72nd-74th | Marcus A. Coolidge (D) | Mar. 4, 1931 | Jan. 3, 1937 | |
| 75th-78th | Henry C. Lodge, Jr. (R) | Jan. 3, 1937 | Feb. 3, 1944 | Resigned |
| 78th | Sinclair Weeks (R) | Feb. 8, 1944 | Dec. 19, 1944 | Appointed |
| 78th-89th | Leverett Saltonstall (R)1 | Jan. 4, 1945 | Jan. 3, 1967 | Appointed |
| 90th-95th | Edward W. Brooke III (R) | Jan. 3, 1967 | Jan. 3, 1979 | |
| 96th-98th | Paul E. Tsongas (D) | Jan. 3, 1979 | Jan. 2, 1985 | Resigned |
| 99th-113th | John F. Kerry (D) | Jan. 2, 19852 | Feb. 1, 2013 | Resigned |
| 113th | William Cowan (Mo) (D) | Feb. 1, 2013 | Jul. 15, 2013 | Appointed |
| 113th- | Edward J. Markey (D) | Jul. 16, 2013 | Present | |
1. Elected Nov. 7, 1944. Took oath of office Jan. 10, 1945. Governor during interim.
2. Elected to full term commencing January 3, 1985; subsequently appointed by governer to fill vacancy in term ending January 3, 1985.
