| CONGRESS | SENATOR | TERM BEGAN | TERM ENDED | COMMENTS |
|---|---|---|---|---|
| Class 1 | ||||
| 17th-31st | Thomas Hart Benton (R, JR, J, D) | Aug. 10, 1821 | Mar. 3, 1851 | |
| 32nd-34th | Henry S. Geyer (W, OP) | Mar. 4, 1851 | Mar. 3, 1857 | |
| 35th-37th | Trusten Polk (D) | Mar. 4, 1857 | Jan. 10, 1862 | Expelled |
| 37th-40th | John B. Henderson (U) | Jan. 17, 1862 | Mar. 3, 1869 | Appointed, then elected |
| 41st-43rd | Carl Schurz (R, LR) | Mar. 4, 1869 | Mar. 3, 1875 | |
| 44th-58th | Francis M. Cockrell (D) | Mar. 4, 1875 | Mar. 3, 1905 | |
| 59th-61st | William Warner (R) | Mar. 18, 19051 | Mar. 3, 1911 | |
| 62nd-70th | James A. Reed (D) | Mar. 4, 1911 | Mar. 3, 1929 | |
| 71st-73rd | Roscoe C. Patterson (R) | Mar. 4, 1929 | Jan. 3, 1935 | |
| 74th-79th | Harry S. Truman (D) | Jan. 3, 1935 | Jan. 17, 19452 | Resigned |
| 79th | Frank P. Briggs (D) | Jan. 18, 1945 | Jan. 3, 1947 | Appointed |
| 80th-82nd | James P. Kem (R) | Jan. 3, 1947 | Jan. 3, 1953 | |
| 83rd-94th | W. Stuart Symington (D) | Jan. 3, 1953 | Dec. 27, 1976 | Resigned |
| 94th-103rd | John C. Danforth (R) | Dec. 27, 19763 | Jan. 3, 1995 | |
| 104th-106th | John D. Ashcroft (R) | Jan. 3, 1995 | Jan. 3, 2001 | |
| 107th | Jean Carnahan (D) | Jan. 3, 20014 | Nov. 23, 2002 | Appointed |
| 107th-109th | James M. Talent (R) | Nov. 23, 2002 | Jan. 3, 2007 | |
| 110th-115th | Claire McCaskill (D) | Jan. 3, 2007 | Jan. 3, 2019 | |
| 116th- | Josh Hawley (R) | Jan. 3, 2019 | Present | |
| Class 3 | ||||
| 17th-21st | David Barton (R, ADAMS-CLAY R, ADAMS, AJ) | Aug. 10, 1821 | Mar. 3, 1831 | |
| 22nd-24th | Alexander Buckner (J) | Mar. 4, 1831 | Jun. 6, 1833 | Died |
| 23rd-28th | Lewis F. Linn (J, D) | Oct. 25, 1833 | Oct. 3, 1843 | Appointed, then elected; died |
| 28th-33rd | David R. Atchison (D) | Oct. 14, 1843 | Mar. 3, 1855 | Appointed, then elected |
| 34th-36th | James S. Green (D) | Jan. 12, 18575 | Mar. 3, 1861 | |
| 37th | Waldo P. Johnson (D) | Mar. 17, 18616 | Jan. 10, 1862 | Expelled |
| 37th-38th | Robert Wilson (U) | Jan. 17, 1862 | Nov. 13, 1863 | Appointed |
| 38th-39th | B. Gratz Brown (UU, R) | Nov. 13, 1863 | Mar. 3, 1867 | |
| 40th-41st | Charles D. Drake (R) | Mar. 4, 1867 | Dec. 19, 1870 | Resigned |
| 41st | Daniel T. Jewett (R) | Dec. 19, 1870 | Jan. 20, 1871 | Appointed |
| 41st-42nd | Francis P. Blair Jr. (D) | Jan. 20, 1871 | Mar. 3, 1873 | |
| 43rd-45th | Lewis V. Bogy (D) | Mar. 4, 1873 | Sept. 20, 1877 | Died |
| 45th | David H. Armstrong (D) | Sept. 29, 1877 | Jan. 26, 1879 | Appointed |
| 45th | James Shields (D) | Jan. 27, 1879 | Mar. 3, 1879 | |
| 46th-57th | George G. Vest (D) | Mar. 4, 1879 | Mar. 3, 1903 | |
| 58th-65th | William J. Stone (D) | Mar. 4, 1903 | Apr. 14, 1918 | Died |
| 65th | Xenophon P. Wilfley (D) | Apr. 30, 1918 | Nov. 5, 1918 | Appointed |
| 65th-69th | Selden P. Spencer (R) | Nov. 6, 1918 | May 16, 1925 | Died |
| 69th | George H. Williams (R) | May 25, 1925 | Dec. 5, 1926 | Appointed |
| 69th-72nd | Harry B. Hawes (D) | Dec. 6, 1926 | Feb. 3, 1933 | Resigned |
| 72nd-78th | Joel Bennett Clark (D) | Feb. 3, 19337 | Jan. 3, 1945 | |
| 79th-81st | Forrest C. Donnell (R) | Jan. 3, 1945 | Jan. 3, 1951 | |
| 82nd-86th | Thomas C. Hennings Jr. (D) | Jan. 3, 1951 | Sept. 13, 1960 | Died |
| 86th-90th | Edward V. Long (D) | Sept. 23, 1960 | Dec. 27, 1968 | Appointed, then elected; resigned |
| 90th-99th | Thomas F. Eagleton (D) | Dec. 28, 19688 | Jan. 3, 1987 | |
| 100th-111th | Christopher S. (Kit) Bond (R) | Jan. 3, 1987 | Jan. 3, 2011 | |
| 112th-117th | Roy Blunt (R) | Jan. 3, 2011 | Jan. 3, 2023 | |
| 118th- | Eric Schmitt (R) | Jan. 3, 2023 | Present | |
1. Vacancy from Mar. 4 to Mar. 17, 1905, because of failure of legislature to elect.
2. Resigned Jan. 17, 1945, having been elected vice president of the United States.
3. Elected to term commencing Jan. 3, 1977, and subsequently appointed by governor, to fill vacancy in term ending Jan. 2, 1977.
4. By governor, to fill vacancy caused by death of husband Mel, who was posthumously elected to term ending Jan. 2, 2007. Defeated in special election.
5. Vacancy from Mar. 4, 1855, to Jan. 12, 1857.
6. Vacancy from Mar. 3 to Mar. 17, 1861.
7. Elected for the term commencing Mar. 4, 1933, and was subsequently appointed to the Senate to fill the vacancy for the term ending Mar. 3, 1933.
8. Elected to term commencing Jan. 3, 1969, and subsequently appointed by governor, to fill vacancy in term ending Jan. 3, 1969.
