| CONGRESS | SENATOR | TERM BEGAN | TERM ENDED | COMMENTS |
|---|---|---|---|---|
| Class 2 | ||||
| 1st-4th | Pierce Butler (PRO-ADMIN, ANTI-ADMIN, R) | Mar. 4, 1789 | Oct. 25, 1796 | Resigned |
| 4th-5th | John Hunter (R) | Dec. 8, 1796 | Nov. 26, 1798 | Resigned |
| 5th-7th | Charles Pinckney (R) | Dec. 6, 1798 | 1801 | Resigned |
| 7th-11th | Thomas Sumter (R) | Dec. 15, 1801 | Dec. 16, 1810 | Resigned |
| 11th-14th | John Taylor (R) | Dec. 31, 1810 | Nov. 1816 | Resigned |
| 14th-17th | William Smith (R) | Dec. 4, 1816 | Mar. 3, 1823 | |
| 18th-23rd | Robert Young Hayne (JR, J, N) | Mar. 4, 1823 | Dec. 13, 1832 | Resigned |
| 22nd-28th | John C. Calhoun (N, D) | Dec. 29, 18321 | Mar. 3, 1843 | Resigned |
| 28th-29th | Daniel Elliott Huger (D) | Mar. 4, 1843 | Mar. 3, 1845 | Resigned |
| 28th-32nd | John C. Calhoun (D) | Nov. 26, 18452 | Mar. 31, 1850 | Died |
| 31st | Franklin H. Elmore (D) | Apr. 11, 1850 | May 29, 1850 | Appointed; died |
| 31st | Robert W. Barnwell (D) | Jun. 4, 1850 | Dec. 18, 1850 | Appointed |
| 31st-32nd | R. Barnwell Rhett (D) | Dec. 18, 1850 | May 7, 1852 | Resigned |
| 32nd | William F. De Saussure (D) | May 10, 1852 | Mar. 3, 1853 | Appointed, then elected |
| 33rd-35th | Josiah J. Evans (D) | Mar. 4, 1853 | May 6, 1858 | Died |
| 35th | Arthur P. Hayne (D) | May 11, 1858 | Dec. 2, 1858 | Appointed |
| 35th-36th | James Chesnut Jr. (D) | Dec. 3, 1858 | Nov. 10, 18603 | |
| 40th-44th | Thomas J. Robertson Jr. (R) | Jul. 15, 18684 | Mar. 3, 1877 | |
| 45th-53rd | Matthew C. Butler (D) | Mar. 4, 1877 | Mar. 3, 1895 | |
| 54th-65th | Benjamin R. Tillman (D) | Mar. 4, 1895 | Jul. 3, 1918 | Died |
| 65th | Christie Benet (D) | Jul. 6, 1918 | Nov. 5, 1918 | Appointed |
| 65th | William P. Pollock (D) | Nov. 6, 1918 | Mar. 3, 1919 | |
| 66th-68th | Nathaniel B. Dial (D) | Mar. 4, 1919 | Mar. 3, 1925 | |
| 69th-71st | Coleman L. Blease (D) | Mar. 4, 1925 | Mar. 3, 1931 | |
| 72nd-77th | James F. Byrnes (D) | Mar. 4, 1931 | Jul. 8, 1941 | Resigned |
| 77th | Alva M. Lumpkin (D) | Jul. 22, 1941 | Aug. 1, 1941 | Appointed; died |
| 77th | Roger C. Peace (D) | Aug. 5, 1941 | Nov. 4, 1941 | Appointed |
| 77th | Burnet R. Maybank (D) | Nov. 5, 1941 | Sept. 1, 1954 | Died |
| 83rd | Charles E. Daniel (D) | Sept. 6, 1954 | Dec. 23, 1954 | Appointed; resigned |
| 83rd-84th | James Strom Thurmond (D) | Dec. 24, 19545 | Apr. 4, 1956 | Resigned |
| 84th | Thomas A. Wofford (D) | Apr. 5, 1956 | Nov. 6, 1956 | Appointed |
| 85th-107th | James Strom Thurmond (D, R) | Nov. 7, 1956 | Jan. 3, 2003 | |
| 108th- | Lindsey O. Graham (R) | Jan. 3, 2003 | Present | |
| Class 3 | ||||
| 1st-3rd | Ralph Izard (PRO-ADMIN) | Mar. 4, 1789 | Mar. 3, 1795 | |
| 4th-6th | Jacob Read (F) | Mar. 4, 1795 | Mar. 3, 1801 | |
| 7th | John Ewing Colhoun (R) | Mar. 4, 1801 | Oct. 26, 1802 | Died |
| 7th-8th | Pierce Butler (R) | Nov. 4, 1802 | Nov. 21, 1804 | Resigned |
| 8th-19th | John Gaillard (R, CRR, J) | Dec. 6, 1804 | Feb. 26, 1826 | Died |
| 19th | William Harper (J) | Mar. 8, 1826 | Nov. 29, 1826 | Appointed |
| 19th-21st | William Smith (R) | Nov. 29, 1826 | Mar. 3, 1831 | |
| 22nd-23rd | Stephen D. Miller (N) | Mar. 4, 1831 | Mar. 2, 1833 | Resigned |
| 23rd-27th | William C. Preston (N, W) | Nov. 26, 1833 | Nov. 29, 1842 | Resigned |
| 27th-29th | George McDuffie (D) | Dec. 2, 1842 | Aug. 17, 1846 | Resigned |
| 29th-35th | Andrew P. Butler (D) | Dec. 4, 18466 | May 25, 1857 | Died |
| 35th-36th | James H. Hammond (D) | Dec. 7, 1857 | Nov. 11, 18607 | |
| 40th-42nd | Frederick A. Sawyer (R) | Jul. 16, 18688 | Mar. 3, 1873 | |
| 43rd-45th | John J. Patterson (R) | Mar. 4, 1873 | Mar. 3, 1879 | |
| 46th-51st | Wade Hampton (D) | Mar. 4, 1879 | Mar. 3, 1891 | |
| 52nd-54th | John L. M. Irby (D) | Mar. 4, 1891 | Mar. 3, 1897 | |
| 55th | Joseph H. Earle (D) | Mar. 4, 1897 | May 20, 1897 | Died |
| 55th-57th | John L. McLaurin (D) | May 27, 1897 | Mar. 3, 1903 | Appointed, then elected |
| 58th-60th | Asbury C. Latimer (D) | Mar. 4, 1903 | Feb. 20, 1908 | Died |
| 60th | Frank B. Gary (D) | Mar. 6, 1908 | Mar. 3, 1909 | |
| 61st-78th | Ellison D. Smith (D) | Mar. 4, 1909 | Nov. 17, 1944 | Died |
| 78th | Wilton E. Hall (D) | Nov. 20, 1944 | Jan. 3, 1945 | Appointed |
| 79th-89th | Olin D. T. Johnston (D) | Jan. 3, 1945 | Apr. 18, 1965 | Died |
| 89th | Donald S. Russell (D) | Apr. 22, 1965 | Nov. 8, 1966 | Appointed |
| 89th-108th | Ernest F. Hollings (D) | Nov. 9, 1966 | Jan. 3, 2005 | |
| 109th-112th | James DeMint (R) | Jan. 3, 2005 | Jan. 1, 2013 | resigned |
| 112th- | Tim Scott (R) | Jan. 2, 20139 | Present | Appointed, then elected |
1. Elected Dec. 12, 1832. Took oath Jan. 4, 1833. Vice president during interim.
2. Vacancy from Mar. 4 to Nov. 26, 1845.
3. Withdrew from the Senate Nov. 10, 1860. Expelled July 11, 1861. Because of Civil War, vacancy from Nov. 10, 1860, to July 14, 1868.
4. By legislature, to fill vacancy in term beginning Mar. 4, 1865. Seated July 20, 1868.
5. Elected on Nov. 2, 1954, to full term beginning Jan. 3, 1955; subsequently appointed by governor to fill vacancy in term ending Jan. 3, 1955.
6. Vacancy from Aug. 17 to Dec. 3, 1846.
7. Withdrew from Senate Nov. 11, 1860. Because of Civil War, vacancy from Nov. 11, 1860, to July 15, 1868.
8. By legislature, to fill vacancy in term beginning Mar. 4, 1867. Seated July 22, 1868.
9. Scott was appointed on January 2, 2013, and resigned his House of Representatives seat that day. His Senate term began before the 112th Congress ended at 12:00 noon on Jan. 3.
