| CONGRESS | SENATOR | TERM BEGAN | TERM ENDED | COMMENTS |
| Class 2 |
| 51st-56th | Richard F. Pettigrew (R, SR) |
Nov.
2, 1889 |
Mar.
3, 1901 | |
| 57th-62nd | Robert J. Gamble (R) |
Mar.
4, 1901 |
Mar.
3, 1913 | |
| 63rd-68th | Thomas Sterling (R) |
Mar.
4, 1913 |
Mar.
3, 1925 | |
| 69th-71st | William H. McMaster (R) |
Mar.
4, 1925 |
Mar.
3, 1931 | |
| 72nd-77th | William J. Bulow (D) |
Mar.
4, 1931 | Jan. 3, 1943 | |
| 78th-80th | Harlan J. Bushfield (R) | Jan. 3, 1943 |
Sept.
27, 1948 | Died |
| 80th | Vera C. Bushfield (R) |
Oct.
6, 1948 |
Dec.
26, 1948 | Appointed; then resigned |
| 80th-92nd | Karl E. Mundt (R) |
Dec.
31, 1948 | Jan. 3, 1973 | |
| 93rd-95th | James Abourezk (D) | Jan. 3, 1973 | Jan. 3, 1979 | |
| 96th-104th | Larry Pressler (R) | Jan. 3, 1979 | Jan. 3, 1997 | |
| 105th-113th | Tim Johnson (D) | Jan. 3, 1997 | Jan. 3, 2015 | |
| 114th- | Mike Rounds (R) | Jan. 3, 2015 |
Present
| |
| Class 3 |
| 51st | Gideon C. Moody (R) |
Nov.
2, 1889 |
Mar.
3, 1891 | |
| 52nd-57th | James H. Kyle (PO, R) |
Mar.
4, 1891 |
Jul.
1, 1901 | Died |
| 57th-60th | Alfred B. Kittredge (R) |
Jul.
11, 1901 |
Mar.
3, 1909 | Appointed, then elected |
| 61st-63rd | Coe I. Crawford (R) |
Mar.
4, 1909 |
Mar.
3, 1915 | |
| 64th-66th | Edwin S. Johnson (D) |
Mar.
4, 1915 |
Mar.
3, 1921 | |
| 67th-74th | Peter Norbeck (R) |
Mar.
4, 1921 |
Dec.
20, 1936 | Died |
| 74th-75th | Herbert E. Hitchcock (D) |
Dec.
29, 1936 |
Nov.
8, 1938 | Appointed |
| 75th | Gladys Pyle (R) |
Nov.
9, 1938 | Jan. 3, 1939 | |
| 76th-81st | J. Chandler Gurney (R) | Jan. 3, 1939 | Jan. 3, 1951 | |
| 82nd-87th | Francis Case (R) | Jan. 3, 1951 |
Jun.
22, 1962 | Died |
| 87th | Joseph H. Bottum (R) |
Jul.
9, 1962 | Jan. 3, 1963 | Appointed |
| 88th-96th | George S. McGovern (D) | Jan. 3, 1963 | Jan. 3, 1981 | |
| 97th-99th | James Abdnor (R) | Jan. 3, 1981 | Jan. 3, 1987 | |
| 100th-108th | Thomas A. Daschle (D) | Jan. 3, 1987 | Jan. 3, 2005 | |
| 109th- | John Thune (R) | Jan. 3, 2005 |
Present
| |
