| WeeksJohn W. Weeks (R-MA) | 19161916 |
| GallingerJacob H. Gallinger (R-NH) | 19181918 |
| PoindexterMiles Poindexter (R, PR-WA) | 1920_19211920–1921 |
| McCormickJ. Medill McCormick (R-IL) | 1921_19221921–1922 |
| MosesGeorge H. Moses (R-NH) | 1922_19241922–1924 |
| FessSimeon D. Fess (R-OH) | 1925_19261925–1926 |
| Phipps Lawrence C. Phipps (R-CO) | 1926_19271926–1927 |
| MosesGeorge H. Moses (R-NH) | 1927_19281927–1928 |
| Metcalf Jesse H. Metcalf (R-RI) | 1928_19291928–1929 |
| MosesGeorge H. Moses (R-NH) | 1929_19301929–1930 |
| NyeGerald P. Nye (R-ND) | 1930_19311930–1931 |
| HatfieldHenry D. Hatfield (R-WV) | 1931_19321931–1932 |
| DickinsonLester J. Dickinson (R-IA) | 1932_1934>1932–1934 |
| HastingsDaniel O. Hastings (R-DE) | 1934_19361934–1936 |
| TownsendJohn G. Townsend, Jr. (R-DE)
1
| 1936_19491936–1949 |
| BrewsterRalph O. Brewster (R-ME) | 1949_19511949–1951 |
| BridgesH. Styles Bridges (R-NH) | 1951_19531951–1953 |
| DirksenEverett M. Dirksen (R-IL) | 1953_19551953–1955 |
| GoldwaterBarry M. Goldwater (R-AZ) | 1955_19561955–1956 |
| SchoeppelAndrew F. Schoeppel (R-KS) | 1956_19591956–1959 |
| GoldwaterBarry M. Goldwater (R-AZ) | 1959_19631959–1963 |
| MortonThruston B. Morton (R-KY) | 1963_19671963–1967 |
| MurphyGeorge L. Murphy (R-CA) | 1967_19691967–1969 |
| TowerJohn G. Tower (R-TX) | 1969_19711969–1971 |
| DominickPeter H. Dominick (R-CO) | 1971_19731971–1973 |
| BrockWilliam E. Brock III (R-TN) | 1973_19751973–1975 |
| StevensTed Stevens (R-AK) | 1975_19771975–1977 |
| PackwoodRobert W. Packwood (R-OR) | 1977_19791977–1979 |
| HeinzH. John Heinz III (R-PA) | 1979_19811979–1981 |
| PackwoodRobert W. Packwood (R-OR) | 1981_19831981–1983 |
| LugarRichard G. Lugar (R-IN) | 1983_19851983–1985 |
| HeinzH. John Heinz III (R-PA) | 1985_19871985–1987 |
| BoschwitzRudy Boschwitz (R-MN) | 1987_19891987–1989 |
| NicklesDonald L. Nickles (R-OK) | 1989_19911989–1991 |
| GrammPhil Gramm (R-TX) | 1991_19951991–1995 |
| D'AmatoAlfonse M. D'Amato (R-NY) | 1995_19971995–1997 |
| McConnellMitch McConnell (R-KY) | 1997_20011997–2001 |
| FristWilliam H. Frist (R-TN) | 2001_20032001–2003 |
| AllenGeorge Allen (R-VA) | 2003_20052003–2005 |
| DoleElizabeth H. Dole (R-NC) | 2005_20072005–2007 |
| EnsignJohn E. Ensign (R-NV) | 2007_20082007–2008 |
| CornynJohn Cornyn (R-TX) | 2009_20132009–2013 |
| MoranJerry Moran (R-KS) | 2013_20152013–2015 |
| WickerRoger F. Wicker (R-MS) | 2015_20172015–2017 |
| GardnerCory Gardner (R-CO) | 2017_20192017–2019 |
| YoungTodd Young (R-IN) | 2019_20212019–2021 |
| ScottRick Scott (R-FL) | 2021_20232021–2023 |
| DainesSteve Daines (R-MT) | 2023_20252023–2025 |
| ScottTim Scott (R-SC) | 2025_2025–present |
