| HaleJohn P. Hale (ID, FS, OP, R-NH) | 1862_1862 ended 1862 |
| AnthonyHenry B. Anthony (R-RI) | 1862_1884 1862–1884 |
| ShermanJohn Sherman (R-OH) | 1884_1885 1884–1885 |
| EdmundsGeorge F. Edmunds (R-VT) | 1885_1891 1885–1891 |
| ShermanJohn Sherman (R-OH) | 1891_1897 1891–1897 |
| AllisonWilliam B. Allison (R-IA) | 1897_1908 1897–1908 |
| HaleEugene Hale (R-ME) | 1908_1911 1908–1911 |
| CullomShelby M. Cullom (R-IL) | 1911_1913 1911–1913 |
| GallingerJacob H. Gallinger (R-NH) | 1913_1918 1913–1918 |
| LodgeHenry C. Lodge (R-MA) | 1918_1924 1918–1924 |
| CurtisCharles Curtis (R-KS) | 1924_1929 1924–1929 |
| WatsonJames E. Watson (R-IN) | 1929_1933 1929–1933 |
| McNaryCharles L. McNary (R-OR) | 1933_1944 1933–1944 |
| VandenbergArthur H. Vandenberg (R-MI) | 1945_1947 1945–1947 1 |
| MillikinEugene D. Millikin (R-CO) | 1947_1957 1947–1957 |
| SaltonstallLeverett Saltonstall (R-MA) | 1957_1967 1957–1967 |
| SmithMargaret Chase Smith (R-ME) | 1967_1973 1967–1973 |
| CottonNorris H. Cotton (R-NH) | 1973_1974 1973–1975 |
| CurtisCarl T. Curtis (R-NE) | 1975_1979 1975–1979 |
| PackwoodRobert W. Packwood (R-OR) | 1979_1981 1979–1980 |
| McClureJames A. McClure (R-ID) | 1981_1985 1981–1985 |
| ChafeeJohn H. Chafee (R-RI) | 1985_1991 1985–1991 |
| CochranThad Cochran (R-MS) | 1991_1997 1991–1997 |
| MackConnie Mack III (R-FL) | 1997_2001 1997–2001 |
| SantorumRick Santorum (R-PA) | 2001_2007 2001–2007 |
| KylJon L. Kyl (R-AZ) | 2007_2007 2007 |
| AlexanderLamar Alexander (R-TN) | 2008_2012 2008–2012 |
| ThuneJohn Thune (R-SD) | 2012_2019 2012–2019 |
| BarrassoJohn Barrasso (R-WY) | 2019_2025 2019–2025 |
| CottonTom Cotton (R-AR) | 2025_ 2025–present |
