| CONGRESS | SENATOR | TERM BEGAN | TERM ENDED | COMMENTS |
|---|---|---|---|---|
| Class 1 | ||||
| 15th-16th | Walter Leake (R) | Dec. 10, 1817 | May 15, 1820 | Resigned |
| 16th-19th | David Holmes (R, JR) | Aug. 30, 1820 | Sept. 25, 1825 | Appointed, then elected; resigned |
| 19th | Powhatan Ellis (J) | Sept. 28, 1825 | Jan. 28, 1826 | Appointed |
| 19th | Thomas B. Reed (J) | Jan. 28, 1826 | Mar. 3, 1827 | |
| 20th-22nd | Powhatan Ellis (J) | Mar. 4, 1827 | Jul. 16, 1832 | Resigned |
| 22nd-25th | John Black (J, AJ, W) | Nov. 12, 1832 | Jan. 22, 1838 | Appointed, then elected; resigned |
| 25th | James F. Trotter (D) | Jan. 22, 1838 | Jul. 10, 1838 | Resigned |
| 25th | Thomas Hickman Williams (D) | Nov. 12, 1838 | Mar. 3, 1839 | Appointed, then elected |
| 26th-28th | John Henderson (W) | Mar. 4, 1839 | Mar. 3, 1845 | |
| 29th-31st | Jesse Speight (D) | Mar. 4, 1845 | May 1, 1847 | Died |
| 30th-32nd | Jefferson Davis (D) | Aug. 10, 1847 | Sept. 23, 1851 | Appointed, then elected; resigned |
| 32nd | John J. McRae (D) | Dec. 1, 1851 | Mar. 17, 1852 | Appointed |
| 32nd-34th | Stephen Adams (D) | Mar. 17, 1852 | Mar. 3, 1857 | |
| 35th-36th | Jefferson Davis (D) | Mar. 4, 1857 | Jan. 21, 18611 | Withdrew |
| 41st-43rd | Adelbert Ames (R) | Feb. 23, 18702 | Jan. 10, 1874 | Resigned |
| 43rd | Henry R. Pease (R) | Feb. 3, 1874 | Mar. 3, 1875 | |
| 44th-46th | Blanche K. Bruce (R) | Mar. 4, 1875 | Mar. 3, 1881 | |
| 47th-55th | James Z. George (D) | Mar. 4, 1881 | Aug. 14, 1897 | Died |
| 55th-61st | Hernando D. Money (D) | Oct. 8, 1897 | Mar. 3, 1911 | Appointed, then elected |
| 62nd-67th | John Sharp Williams (D) | Mar. 4, 1911 | Mar. 3, 1923 | |
| 68th-73rd | Hubert D. Stephens (D) | Mar. 4, 1923 | Jan. 2, 1935 | |
| 74th-82nd | Theodore G. Bilbo (D) | Jan. 3, 1935 | Aug. 21, 19473 | Died |
| 80th-100th | John C. Stennis (D) | Nov. 5, 1947 | Jan. 2, 1989 | |
| 101st-110th | Trent Lott (R) | Jan. 3, 1989 | Dec. 18, 2007 | Resigned |
| 110th- | Roger F. Wicker (R) | Dec. 31, 2007 | Present | Appointed, then elected |
| Class 2 | ||||
| 15th-20th | Thomas Hill Williams (R, JR, J) | Dec. 10, 1817 | Mar. 3, 1829 | |
| 21st | Thomas B. Reed (J) | Mar. 4, 1829 | Nov. 26, 1829 | Died |
| 21st | Robert H. Adams (J) | Jan. 6, 1830 | Jul. 2, 1830 | Died |
| 21st-23rd | George Poindexter (J, AJ) | Oct. 15, 1830 | Mar. 3, 1835 | Appointed, then elected |
| 24th-29th | Robert J. Walker (J, D) | Mar. 4, 1835 | Mar. 5, 1845 | Resigned |
| 29th | Joseph W. Chalmers (D) | Nov. 3, 1845 | Mar. 3, 1847 | Appointed, then elected |
| 30th-32nd | Henry Stuart Foote (D) | Mar. 4, 1847 | Jan. 8, 1852 | Resigned |
| 32nd | Walker Brooke (W) | Feb. 18, 1852 | Mar. 3, 1853 | |
| 33rd-36th | Albert G. Brown (D) | Jan. 7, 18544 | Jan. 12, 18615 | Withdrew |
| 41st | Hiram R. Revels (R) | Feb. 23, 18706 | Mar. 3, 1871 | |
| 42nd-44th | James L. Alcorn (R) | Dec. 4, 18717 | Mar. 3, 1877 | |
| 45th-50th | Lucius Q.C. Lamar (D) | Mar. 4, 1877 | Mar. 6, 1885 | Resigned |
| 49th-53rd | Edward C. Walthall (D) | Mar. 9, 1885 | Jan. 24, 1894 | Appointed, then elected; resigned |
| 53rd | Anselm J. McLaurin (D) | Feb. 7, 1894 | Mar. 3, 1895 | |
| 54th-55th | Edward C. Walthall (D) | Mar. 4, 1895 | Apr. 21, 1898 | Died |
| 55th-56th | William V. Sullivan (D) | May 31, 1898 | Mar. 3, 1901 | Appointed, then elected |
| 57th-61st | Anselm J. McLaurin (D) | Mar. 4, 1901 | Dec. 22, 1909 | Died |
| 61st | James Gordon (D) | Dec. 27, 1909 | Feb. 22, 1910 | Appointed |
| 61st-62nd | LeRoy Percy (D) | Feb. 23, 1910 | Mar. 3, 1913 | |
| 63rd-65th | James K. Vardaman (D) | Mar. 4, 1913 | Mar. 3, 1919 | |
| 66th-77th | Byron P. Harrison (D) | Mar. 4, 1919 | Jun. 22, 1941 | Died |
| 77th | James O. Eastland (D) | Jun. 30, 1941 | Sept. 28, 1941 | Appointed |
| 77th | Wall Doxey (D) | Sept. 29, 1941 | Jan. 2, 1943 | |
| 78th-95th | James O. Eastland (D) | Jan. 3, 1943 | Dec. 27, 1978 | Resigned |
| 99th-115thth | William Thad Cochran (R) | Dec. 27, 19788 | Apr. 1, 2018 | |
| 115th- | Cindy Hyde-Smith (R) | Apr. 9, 20189 | Present | Appointed, then elected |
1. Withdrew from the Senate Jan. 21, 1861. Seat declared vacant Mar. 14, 1861. Because of Civil War, vacancy from Jan. 21, 1861, to Feb. 23, 1870, when Mississippi was readmitted to representation.
2. By legislature, to fill vacancy in term beginning Mar. 4, 1869. Credentials challenged; seated April 1, 1870.
3. Oath not administered for term beginning Jan. 3, 1947 due to contested election. Died Aug. 21, 1947.
4. Vacancy from Mar. 4, 1853, to Jan. 7, 1854, because of legislature's failure to elect. Brown was elected on Jan. 7 and took his seat Jan. 26.
5. Withdrew from the Senate Jan. 12, 1861. Seat declared vacant Mar. 14, 1861. Because of Civil War, vacancy from Jan. 14, 1861, to Feb. 23, 1870, when Mississippi was readmitted to representation.
6. By legislature to fill vacancy in term beginning Mar. 4, 1865. Credentials challenged; seated Feb. 25, 1870.
7. Elected Jan. 18, 1870, for term beginning Mar. 4, 1871. Took oath Dec. 4, 1871. Governor during interim.
8. Elected to term commencing Jan. 3, 1979 and subsequently appointed by governor to fill vacancy in term ending Jan. 2, 1979.
9. Appointed on April 2, 2018, and was sworn into office on April 9, 2018.
